CD70 (clone EBS-CD-039), anti-human

Source:
A BALB/c mouse was immunized with human WM-1 (Waldenstrom’s macroglobulinemia) cells.
Fusion partner: NS-1.



Specifications:
CD70 is a 30 kDa cytokine that belongs to the tumor necrosis factor (TNF) ligand family. CD70 is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and b-lymphocytes. It induces proliferation of co-stimulated T-cells, enhaces the generation of cytolytic T-cells, and constributes to T-cell activation. It futher plays a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. EBS-CD-039 blocks the interaction between CD27 and CD70, and has been shown to inhibit T-cell proliferation induced by dendritic cells.

Species reactivity:
Positive: human.

Applications:
Demonstration of CD70.ELISA
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Immunoprecipitation: +

Positive control: Raji cells, lymph node or tonsil.

References:
- R.Q. Hintzen, et al, J Immunol 152: 1762-1773 (1994).
- M.R. Bowman, et al, J Immunol 152: 1756-1761 (1994).
- Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1137-1138.
- K. Agematsu, et al, J Immunol 154: 3627-3635 (1995)