CD70 / TNFSF7 (Activated T- & B-Lymphocyte Marker) (clone BU69 ), anti-human

Background:
It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This MAb blocks the interaction between CD27 and CD70, and has been shown toĀinhibit T cell proliferation induced by dendritic cells.

Other Names:
CD70 antigen, CD27 ligand, CD27-L, Tumor necrosis factor ligand superfamily member 7, CD70, CD70, CD27L, CD27LG, TNFSF7

Gene Name: CD70 (HGNC:11937)
Gene ID: 970
Primary Accession: P32970
Other Accession: 970, 501497, 715224