CD71 (Transferrin Receptor) (clone 66IG10), anti-human
€564.00
In stock
SKU
ARP-21-5258
Catalog Number: 21-5258
Size: 100 µg
Isotype: Mouse IgG1
Size: 100 µg
Isotype: Mouse IgG1
Background:
Transferrin receptor protein 1 (TfR1) also known as CD71 (Cluster of Differentiation 71) is a protein that in Humans is encoded by the TFRC gene. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron-carrying protein. The expression of CD71 is regulated at the post-transcriptional level through the control of mRNA stability and is closely linked to intracellular iron levels. Nitric oxide can affect CD71 expression independently of intracellular iron concentRation by activating proteins which then stabilize CD71 mRNA. Expression of CD71, or the transferrin receptor, is very low on resting leukocytes but is upregulated upon activation reflecting the iron dependence of activation. In other tissues, CD71 is expressed on most dividing cells and also on brain endothelium and alveolar macrophage. The ligand is the Serum iron transport protein transferrin. CD71 antibodies are used as an indiCator of proliferation in the typing of lymphomas and leukemias.
Clone: 66IG10
Isotype: Mouse IgG1
Source: 66IG10 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with Human T-cells.
Reactivity: human
Specificity: 66IG10, raised anti Human thymocytes (T-cells) was found to be directed anti the Human transferrin receptor. This antibody reacts with the transferrin receptor, a 180-190 kD transmembrane glycoprotein which exists as a 95 kD homodimer with interchain disulfide bond.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunohistochemistry (frozen), Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
Transferrin receptor protein 1 (TfR1) also known as CD71 (Cluster of Differentiation 71) is a protein that in Humans is encoded by the TFRC gene. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron-carrying protein. The expression of CD71 is regulated at the post-transcriptional level through the control of mRNA stability and is closely linked to intracellular iron levels. Nitric oxide can affect CD71 expression independently of intracellular iron concentRation by activating proteins which then stabilize CD71 mRNA. Expression of CD71, or the transferrin receptor, is very low on resting leukocytes but is upregulated upon activation reflecting the iron dependence of activation. In other tissues, CD71 is expressed on most dividing cells and also on brain endothelium and alveolar macrophage. The ligand is the Serum iron transport protein transferrin. CD71 antibodies are used as an indiCator of proliferation in the typing of lymphomas and leukemias.
Clone: 66IG10
Isotype: Mouse IgG1
Source: 66IG10 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with Human T-cells.
Reactivity: human
Specificity: 66IG10, raised anti Human thymocytes (T-cells) was found to be directed anti the Human transferrin receptor. This antibody reacts with the transferrin receptor, a 180-190 kD transmembrane glycoprotein which exists as a 95 kD homodimer with interchain disulfide bond.
Form: Each vial contains 100ul purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applications: Flow Cytometry, Immunohistochemistry (frozen), Immunoprecipitation, Western blotting
Storage: Store at 4C, or in small aliquots at -20C.
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