CD8 (clone H5), anti-mouse

Background:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.

Decription:
Rat monoclonal Antibody to mouse CD8

Synonyms: CD8A, CD8

Clone: H5

Isotype: Rat IgM

Immunogen: Con A-activated, CD4+ and B Cell-depleted Mouse LN cells

Reactivity: mouse

Specificity: Mouse CD 8 (recognizes both Lyt-2 alleles)

Form: Affinity Purified, in PBS containing 0.5% BSA and 0.1% Sodium Azide

Applications: Staining, sorting, panning, immunoprecipitation, and antibody mediated cytotoxicity

Storage: 2-8C for immediate use; or at -20C (aliquot) Avoid freeze-thaw cycles