CD81 / TAPA-1 (clone 1.3.3.22), anti-human, mouse, rat
€0.00
In stock
SKU
AC-AH13650
Catalog Number: AC-AH13650
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: 1.3.3.22
Applications: WB, IHC-P, IF, FC
Datasheet
Request Information
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: 1.3.3.22
Applications: WB, IHC-P, IF, FC
Datasheet
Request Information
Background:
Recognizes a protein of 26kDa, identified as CD81 (Workshop VI; Code CD81.1)). CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.
Other Names:
CD81; Target of the antiproliferative antibody 1 (TAPA-1); Tetraspanin-28; Tspan-28
Gene Name: CD81 {ECO:0000303|PubMed:8766544, ECO:0000312|HGNC:HGNC:1701}
Gene ID: 975
Primary Accession: P60033
Other Accession: 54457
Recognizes a protein of 26kDa, identified as CD81 (Workshop VI; Code CD81.1)). CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.
Other Names:
CD81; Target of the antiproliferative antibody 1 (TAPA-1); Tetraspanin-28; Tspan-28
Gene Name: CD81 {ECO:0000303|PubMed:8766544, ECO:0000312|HGNC:HGNC:1701}
Gene ID: 975
Primary Accession: P60033
Other Accession: 54457
| Is Featured? | No |
|---|
Write Your Own Review