CD86 Polyclonal Antibody

Background:
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Research Area: Cancer, Immunology, Microbiology, Stem cells

Synonyms:
B7-2, B7.2, B70, CD28LG2, LAB72, CD86

Immunogen: Recombinant fusion protein of human CD86 (NP_787058.4).

Swissprot: P42081
Gene ID: 942

Calculated MW: 12 kDa/24 kDa/28 kDa/31 kDa/37 kDa
Observed MW: 68 kDa/80 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.