CD87 (uPA Receptor) polyclonal, anti-human

Quantity: 100 µg

Background:
PLAUR(PLASMINOGEN ACTIVATOR RECEPTOR, UROKINASE-TYPE), also known as UPAR or CD87, is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol(GPI) anchor. PLAUR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. PLAUR is originally identified as a saturable binding site for urokinase on the cell surface. And the gene plays an important role in many normal as well as pathologic processes. The PLAUR gene is localized to 19q13.31. PLAUR is a part of the plasminogen activation system, which in the healthy body is involved in tissue reorganization events such as mammary gland involution and wound healing. PLAUR binds urokinase and thus restricts plasminogen activation to the immediate vicinity of the cell membrane. Thus it seems to be an important player in the regulation of this process. In human coronary artery vascular smooth muscle cells, UPA stimulates cell migration via a UPAR signaling complex containing TYK2 and phosphatidylinositol 3-kinase.

Description:
Rabbit IgG polyclonal antibody for Urokinase plasminogen activator surface receptor (PLAUR) detection. Tested with WB, IHC-P in Human.

Synonyms:
CD87 antibody, CD87 antibody, CD87 antigen antibody, MO 3 antibody, MO3 antibody, Monocyte activation antigen Mo3 antibody, Plasminogen activator urokinase receptor antibody, PLAUR antibody, U PAR antibody, u plasminogen activator receptor antibody, U-PAR antibody, UPA receptor antibody, UPAR antibody, UPAR_HUMAN antibody, Urinary plasminogen activator receptor antibody, URKR antibody, Urokinase plasminogen activator receptor antibody, Urokinase plasminogen activator surface receptor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human uPA Receptor(293-304aa CNHPDLDVQYRS).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.