CD8B (Cytotoxic / Suppressor T-Cell Marker) (clone BU88 ), anti-human

Background:
The T cell receptor (TCR) is a heterodimer composed of either Ī � and Ī � or Ī � and Ī � chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8. T helper cells express CD4 proteins and T cytotoxic cells display CD8. CD8 (also designated Leu 2 or T8), a cell surface glycoprotein, is a two chain complex (Ī �-Ī � or Ī �-Ī �) receptor that binds class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.

Other Names:
T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1

Gene Name: CD8B
Gene ID: 926
Primary Accession: P10966
Other Accession: 926, 405667