CD8B polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60358
Background:
The T cell receptor (TCR) is a heterodimercomposed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficientsignal transduction through the TCR. The TCR is expressed on T helper and T cytotoxiccellsthatcan be distinguished bytheir expression of CD4 and CD8. T helpercells express CD4 proteins and T cytotoxiccells display CD8. CD8 (also designated Leu 2 or T8), a cellsurface glycoprotein, is a two chain complex(αα or αβ) receptor that bindsclassI MHC molecules presented bythe antigen-presenting cell (APC). A primaryfunction of CD8 is to facilitate antigen recognition bythe TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cellsmay be tomaintain lowlevels of HIV expression.
Alternative Name:
T-cell surface glycoprotein CD8 beta chain, CD_antigen=CD8b, CD8B , CD8B1
Application Dilution: WB: 1:500~1:1000
Specificity: CD8B polyclonal antibody detects endogenous levels of CD8B protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CD8B.
MW: ~ 26 kDa
Swis Prot.: P10966
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The T cell receptor (TCR) is a heterodimercomposed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficientsignal transduction through the TCR. The TCR is expressed on T helper and T cytotoxiccellsthatcan be distinguished bytheir expression of CD4 and CD8. T helpercells express CD4 proteins and T cytotoxiccells display CD8. CD8 (also designated Leu 2 or T8), a cellsurface glycoprotein, is a two chain complex(αα or αβ) receptor that bindsclassI MHC molecules presented bythe antigen-presenting cell (APC). A primaryfunction of CD8 is to facilitate antigen recognition bythe TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cellsmay be tomaintain lowlevels of HIV expression.
Alternative Name:
T-cell surface glycoprotein CD8 beta chain, CD_antigen=CD8b, CD8B , CD8B1
Application Dilution: WB: 1:500~1:1000
Specificity: CD8B polyclonal antibody detects endogenous levels of CD8B protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CD8B.
MW: ~ 26 kDa
Swis Prot.: P10966
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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