CD8B1 polyclonal (C-term), anti-human

Background:
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.

Other Names:
T-cell surface glycoprotein CD8 beta chain, CD8b, CD8B, CD8B1

Target/Specificity:
This CD8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-167 amino acids from the C-terminal region of human CD8B1.

Antigen Region:
141-167

Antigen Type: Synthetic Peptide

Gene Name: CD8B
Gene ID: 926
Primary Accession: P10966
NCBI Accession: NP_001171571.1;NP_004922.1;NP_742099.1;NP_742100.1;NP_757362.1
Other Accession: A6NJW9; NP_004922
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.