CD91 (LRP1) polyclonal, anti-human

Quantity: 100 µg

Background:
LRP1, also known as Low density lipoprotein receptor-related protein 1 or CD91, is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. It is mapped to 12q13.3. In humans, the LRP1 protein is encoded by the LRP1 gene. It is mapped to 12q13.3. LRP1 is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. LRP1 showed strong calcium binding. It mediates the endocytosis and degradation of secreted amyloid precursor protein, suggesting that a single metabolic pathway links 2 molecules implicated in the pathophysiology of Alzheimer disease, LRP1 has a role in macrophage migration and that it is critical for internalization of integrin alpha-M/beta-2.

Description:
Rabbit IgG polyclonal antibody for Prolow-density lipoprotein receptor-related protein 1 (LRP1) detection. Tested with WB in Human.

Synonyms:
A2MR antibody, Alpha 2 macroglobulin receptor antibody, alpha 2MR antibody, Alpha-2-macroglobulin receptor antibody, APOER antibody, Apolipoprotein E receptor antibody, APR antibody, CD 91 antibody, CD91 antibody, CD91 antigen antibody, IGFBP3R antibody, Low density lipoprotein receptor related protein 1 antibody, Low density lipoprotein related protein 1 antibody, Low-density lipoprotein receptor-related protein 1 intracellular domain antibody, LRP 1 antibody, LRP 515 antibody, LRP 85 antibody, LRP antibody, LRP ICD antibody, LRP-1 antibody, LRP-515 antibody, LRP-85 antibody, Lrp1 antibody, LRP1 protein antibody, LRP1_HUMAN antibody, LRP1A antibody, LRP515 antibody, LRP85 antibody, LRPICD antibody, MGC88725 antibody, TbetaR V/LRP 1/IGFBP 3 receptor antibody, TbetaRV/LRP1/IGFBP3 receptor antibody, TGFBR 5 antibody, TGFBR5 antibody, Type V tgf beta receptor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human LRP1 recombinant protein (Position: A4351-A4544). Human LRP1 shares 86% amino acid (aa) sequence identity with mouse LRP1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.