CD91 (RAP/Pleo-Lipoprotein Receptor) polyclonal, anti-human: CD91, chicken: LR8, rat: gp330

Quantity: 50 µl

Background:
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients.

Synonyms:
LRP1, APR, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R

Isotype: Rabbit Polyclonal

Immunogen:
Recombinant human RAP (receptor-associated protein)

Form: Stabilized Serum

Specificity:
The antibody binds to an epitope of the C-terminal part of RAP, a sequence common to the human VLDL receptor superfamily (glycoprotein 330 and LRP), the chicken oocyte receptor for VLDL and vitellogenin (LR8), and glycoprotein 330/megalin from rat. No reaction with LDL receptor.

Reactivity: human: RAP, CD91 (LRP), VLDL-R, chicken: LR8, rat: gp330

Applications: Immunohistochemistry, suitable for frozen and paraffin sections, Ligand blotting, Immunoblotting (western)

Working DIlution: 1:50 to 1:100

Positive Control:
Formalin-fixed paraffin sections of cat Illeum

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Hiesberger, T. et al. (1996) J. Biol. Chem. 271: 28792-28797