CDC42 polyclonal, anti-human, bovine, mouse, rat

Quantity: 100 µg

Background:
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene. CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein(N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

Description:
Rabbit IgG polyclonal antibody for Cell division control protein 42 homolog (CDC42) detection. Tested with WB, IHC-P in Human, Bovin, Mouse, Rat.

Synonyms:
CDC 42 antibody, CDC42 antibody, CDC42_HUMAN antibody, CDC42Hs antibody, Cell division control protein 42 homolog antibody, Cell division cycle 42(GTP binding protein 25kDa) antibody, Cell division cycle 42 antibody, Cell division cycle 42 isoform 1 antibody, Cell division cycle 42 isoform 2 antibody, dJ224A6.1.1(cell division cycle 42(GTP-binding protein, 25kD)) antibody, dJ224A6.1.1 antibody, dJ224A6.1.2(cell division cycle 42(GTP-binding protein, 25kD)) antibody, dJ224A6.1.2 antibody, G25K antibody, G25K GTP binding protein antibody, G25K GTP-binding protein antibody, Growth regulating protein antibody, GTP binding protein 25kD antibody, GTP binding protein 25kDa antibody, Small GTP binding protein CDC42 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human CDC42(121-138aa DDPSTIEKLAKNKQKPIT), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, bovine, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.