CDH1 (clone 7H12), anti-human, mouse, monkey
€0.00
In stock
SKU
BT-MCA3470
Catalog Number: BT-MCA3470
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human, mouse, monkey
Application(s): WB, IHC, FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human, mouse, monkey
Application(s): WB, IHC, FCM
Datasheet
Request Information
Background:
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Research Area: Signal transduction, Cancer, Developmental biology
Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Research Area: Signal transduction, Cancer, Developmental biology
Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
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