CDH12 Polyclonal Antibody

Background:
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Research Area: Signal Transduction

Synonyms:
Br cadherin, BR-cadherin, Brain cadherin, CAD12_HUMAN, cadherin 12 (N cadherin 2), Cadherin 12, Cadherin 12 precursor, Cadherin 12 type 2 (N cadherin 2), Cadherin 12 type 2, Cadherin neural type 2, Cadherin-12, CDH12, CDHB, FLJ34857, N cadherin 2, N-cadherin 2, Neural type cadherin 2, Neuronal cadherin 2

Immunogen: Synthetic peptide of human CDH12

Swissprot: P55289
Gene Accession: NP004052

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.74 mg/mL
Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.