CDHF10 rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008],function:Receptor that may have an important role in cell/cell signaling during nervous system formation.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 1 laminin EGF-like domain.,similarity:Contains 2 laminin G-like domains.,similarity:Contains 7 EGF-like domains.,similarity:Contains 9 cadherin domains.,tissue specificity:Highest expression in brain and testis.,

Synonyms: CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3, Cadherin EGF LAG seven-pass G-type receptor 2, Cadherin family member 10, Epidermal growth factor-like protein 2, EGF-like protein 2, Flamingo homolog 3, Multiple epidermal growth factor-like domains

Gene Name: CELSR2

Gene ID: 1952

SwissProt ID: Q9HCU4

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.