CDK3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60071
Background:
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2–Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk3, like Cdk2, is known to be required for the G1–S transition. Proteins involved in cell cycle control have become the subject of increased interest with regard to their potential roles in tumorigenesis. Both Cdk3 and Cdk2 have been mapped to regions of a human chromosome that may be altered in a variety of tumors.
Alternative Name:
Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3
Application Dilution: WB: 1:500~1:1000
Specificity: CDK3 polyclonal antibody detects endogenous levels of CDK3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CDK3.
MW: ~ 35 kDa
Swis Prot.: Q00526
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2–Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Cdk3, like Cdk2, is known to be required for the G1–S transition. Proteins involved in cell cycle control have become the subject of increased interest with regard to their potential roles in tumorigenesis. Both Cdk3 and Cdk2 have been mapped to regions of a human chromosome that may be altered in a variety of tumors.
Alternative Name:
Cyclin-dependent kinase 3, Cell division protein kinase 3, CDK3, CDKN3
Application Dilution: WB: 1:500~1:1000
Specificity: CDK3 polyclonal antibody detects endogenous levels of CDK3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human CDK3.
MW: ~ 35 kDa
Swis Prot.: Q00526
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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