CDK4 antibody (clone 2G7), anti-human, mouse
€435.00
In stock
SKU
AC-AT1475a
Catalog Number: AC-AT1475a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IF, E
Request Information AC-AT1475a">Request Information
Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Other Names:
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
Antigen Type:
Recombinant Protein
Gene Name: CDK4
Gene ID: 1019
NCBI Accession: NP_000066.1
Primary Accession: P11802
Other Accession: BC003644
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Other Names:
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
Antigen Type:
Recombinant Protein
Gene Name: CDK4
Gene ID: 1019
NCBI Accession: NP_000066.1
Primary Accession: P11802
Other Accession: BC003644
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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