CDK4 (clone 4G9F1), anti-
€0.00
In stock
SKU
BT-MCA3483
Catalog Number: BT-MCA3483
Size(s): 50μL, 100μL
Isotype: Mouse IgG2a
Reactivity:
Application(s): WB, IHC, FCM
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG2a
Reactivity:
Application(s): WB, IHC, FCM
Datasheet
Request Information
Background:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Research Area: Cell Biology
Synonyms: CMM3, PSK-J3
Immunogen: Purified recombinant fragment of human CDK4 (AA: 77-303) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
Research Area: Cell Biology
Synonyms: CMM3, PSK-J3
Immunogen: Purified recombinant fragment of human CDK4 (AA: 77-303) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
Storage:
4°C|-20°C for long term storage
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