CDK4 monoclonal, anti-human, mouse
€0.00
In stock
SKU
AC-AM8485b
Catalog Number: AC-AM8485b
Size: 50 µl, 200 µl
Isotype: mouse IgG2a,κ
Clone Name: 1529CT850.162.73
Applications: WB, IHC-P
Datasheet
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Size: 50 µl, 200 µl
Isotype: mouse IgG2a,κ
Clone Name: 1529CT850.162.73
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Other Names:
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
Target/Specificity:
This CDK4 antibody is generated from a mouse immunized with a recombinant protein.
Gene Name: CDK4
Gene ID: 1019
Primary Accession: P11802
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Other Names:
Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4
Target/Specificity:
This CDK4 antibody is generated from a mouse immunized with a recombinant protein.
Gene Name: CDK4
Gene ID: 1019
Primary Accession: P11802
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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