Cdk4 Polyclonal Antibody
€0.00
In stock
SKU
ELK-ES3928
Catalog Number: ELK-ES3928
Reactivity: Human, Mouse, Rat
Applications: IF, WB, IHC-p, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Reactivity: Human, Mouse, Rat
Applications: IF, WB, IHC-p, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Background:
cyclin dependent kinase 4(CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],
Alternative Names:
CDK4, Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3
Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human CDK4. AA range:1-50
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 35
GeneID: CDK4
Storage: -20°C/1 year
NOTE: For Research Use Only
cyclin dependent kinase 4(CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],
Alternative Names:
CDK4, Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3
Immunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human CDK4. AA range:1-50
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
Observed band: 35
GeneID: CDK4
Storage: -20°C/1 year
NOTE: For Research Use Only
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