Neuralized-1 polyclonal, anti-human
€470.00
In stock
SKU
AC-AP71235
Background:
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Other Names:
NEURL; NEURL1; NEURL1A; RNF67; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67
Antigen Type: synthetic peptide
Antigen Type: NEURL1
Gene ID: 9148
Primary Accession: O76050
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Other Names:
NEURL; NEURL1; NEURL1A; RNF67; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67
Antigen Type: synthetic peptide
Antigen Type: NEURL1
Gene ID: 9148
Primary Accession: O76050
| Is Featured? | No |
|---|
Write Your Own Review