CDK6 antibody (clone 8H4), anti-human, rat
€435.00
In stock
SKU
AC-AT1478a
Catalog Number: AC-AT1478a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF
Request Information AC-AT1478a">Request Information
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF
Request Information AC-AT1478a">Request Information
Background:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Other Names:
Cyclin-dependent kinase 6, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, CDK6, CDKN6
Antigen Type:
Recombinant Protein
Gene Name: CDK6
Gene ID: 1021
NCBI Accession: NP_001138778.1;NP_001250.1
Primary Accession: Q00534
Other Accession: NM_001259
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Other Names:
Cyclin-dependent kinase 6, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, CDK6, CDKN6
Antigen Type:
Recombinant Protein
Gene Name: CDK6
Gene ID: 1021
NCBI Accession: NP_001138778.1;NP_001250.1
Primary Accession: Q00534
Other Accession: NM_001259
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
| Is Featured? | No |
|---|
Write Your Own Review