CDK6 polyclonal, anti-human

Background:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation;promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation;prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles.

Synonyms: CDKN6, Cyclin-dependent kinase 6, Cell division protein kinase 6

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human CDK6

Gene Symbol: CDK6

Gene ID: 1021

Swiss prot: Q00534

Calculated MW: 37kDa

Recommended dilution:
WB 1:5000-8000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.