CDK6 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Synonyms: MCPH12, PLSTIRE

Cellular Location: Cell projection Cytoplasm Nucleus centrosome cytoskeleton microtubule organizing center ruffle

Immunogen:
Recombinant protein of human CDK6

Gene Symbol: CDK6

Gene ID: 1021

Swiss prot: Q00534

Calculated MW: 37kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-200, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.