CDK8 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP11972c
Background:
The protein encoded by this gene is a member of thecyclin-dependent protein kinase (CDK) family. CDK family membersare highly similar to the gene products of Saccharomyces cerevisiaecdc28, and Schizosaccharomyces pombe cdc2, and are known to beimportant regulators of cell cycle progression. This kinase and itsregulatory subunit cyclin C are components of the RNA polymerase IIholoenzyme complex, which phosphorylates the carboxy-terminaldomain (CTD) of the largest subunit of RNA polymerase II. Thiskinase has also been shown to regulate transcription by targetingthe CDK7/cyclin H subunits of the general transcription initiationfactor IIH (TFIIH), thus providing a link between the'Mediator-like' protein complexes and the basal transcriptionmachinery.
Other Names:
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, CDK8
Gene Name: CDK8
Gene ID: 1024
Primary Accession: P49336
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of thecyclin-dependent protein kinase (CDK) family. CDK family membersare highly similar to the gene products of Saccharomyces cerevisiaecdc28, and Schizosaccharomyces pombe cdc2, and are known to beimportant regulators of cell cycle progression. This kinase and itsregulatory subunit cyclin C are components of the RNA polymerase IIholoenzyme complex, which phosphorylates the carboxy-terminaldomain (CTD) of the largest subunit of RNA polymerase II. Thiskinase has also been shown to regulate transcription by targetingthe CDK7/cyclin H subunits of the general transcription initiationfactor IIH (TFIIH), thus providing a link between the'Mediator-like' protein complexes and the basal transcriptionmachinery.
Other Names:
Cyclin-dependent kinase 8, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, CDK8
Gene Name: CDK8
Gene ID: 1024
Primary Accession: P49336
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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