CDK8 C-terminal region polyclonal, anti-human, mouse, rabbit, pig, horse, bovine, dog

Background:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

Other Names:
Cyclin-dependent kinase 8, 2.7.11.22, 2.7.11.23, Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35, CDK8

Immunogen:
The immunogen for anti-CDK8 antibody: synthetic peptide directed towards the C terminal of human CDK8

Gene Name:
CDK8
Gene Name:
1024
NCBI Accession:
NP_001251
Primary Accession: P49336
Other Accession: NM_001260;NP_001251
Purification: Protein A purified
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.