CDK9 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7525b
Background:
CDK9, a member of the CDC2/CDKX subfamily of Ser/Thr protein kinases, is a component of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The CDK9/cyclin K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFB in vitro. In vitro, this protein phosphorylates retinoblastoma and myelin basic protein.
Other Names:
Cyclin-dependent kinase 9, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, CDK9, CDC2L4, TAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7525b was selected from the C-term region of human CDK9 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CDK9 {ECO:0000303|PubMed:10903437, ECO:0000312|HGNC:HGNC:1780}
Gene ID: 1025
Primary Accession: P50750
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CDK9, a member of the CDC2/CDKX subfamily of Ser/Thr protein kinases, is a component of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). The CDK9/cyclin K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFB in vitro. In vitro, this protein phosphorylates retinoblastoma and myelin basic protein.
Other Names:
Cyclin-dependent kinase 9, C-2K, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, CDK9, CDC2L4, TAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7525b was selected from the C-term region of human CDK9 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CDK9 {ECO:0000303|PubMed:10903437, ECO:0000312|HGNC:HGNC:1780}
Gene ID: 1025
Primary Accession: P50750
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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