CDKN1B polyclonal, anti-human, mouse, rat

Background:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Synonyms: CDKN4, KIP1, MEN1B, MEN4, P27KIP1

Cellular Location: Cytoplasm Endosome Nucleus

Immunogen:
Recombinant protein of human CDKN1B

Gene Symbol: CDKN1B

Gene ID: 1027

Swiss prot: P46527

Calculated MW: 22kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:20-50,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.