CDKN2AIP Polyclonal Antibody

Background:
CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
Calcium response factor, CARF, CARF, CDKN2A interacting protein, CDKN2A-interacting protein, Cdkn2aip, collaborates/cooperates with ARF (alternate reading frame) protein, Collaborator of ARF, FLJ20036

Immunogen: Recombinant protein of human CDKN2AIP

Swissprot: Q9NXV6
Gene Accession: BC022270

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-161477/sc-161478