CDKN2C polyclonal, anti-human, mouse

Background:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Synonyms: CDKN2C, p18 INK, INK4C, p18, cyclin dependent kinase inhibitor 2C

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human CDKN2C

Gene Symbol: CDKN2C

Gene ID: 1031

Swiss prot: P42773

Calculated MW: 18kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.