CDw17 (Lactosylceramide or LacCer) (clone HO18.3G-6.F5) , anti-human
€0.00
In stock
SKU
ARP-24-MSM2-1092
Catalog Number: 24-MSM2-1092
Size: 100 µl, 0.5 ml, 1 ml
Isotype: Mouse IgM
Size: 100 µl, 0.5 ml, 1 ml
Isotype: Mouse IgM
Decription:
CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor Ī � (TNFĪ �)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
Synonyms: Lactosylceramide, LacCer, �-D-galactosyl-(1-4)-�-D-glucosyl-(1-1')-ceramide, CDw17
Clone: HO18.3G-6.F5
Isotype: Mouse IgM
Immunogen: β-2 Microglobulin associated proteins from a detergent lysate of human PBL
Reactivity: human. Others not known.
Form: Purified, in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applications: Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Optimal dilution for a specific application should be determined.
Reactivity: Human PBL. Tonsil
Concentration: 0.2mg/ml
Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor Ī � (TNFĪ �)-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.
Synonyms: Lactosylceramide, LacCer, �-D-galactosyl-(1-4)-�-D-glucosyl-(1-1')-ceramide, CDw17
Clone: HO18.3G-6.F5
Isotype: Mouse IgM
Immunogen: β-2 Microglobulin associated proteins from a detergent lysate of human PBL
Reactivity: human. Others not known.
Form: Purified, in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Applications: Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Optimal dilution for a specific application should be determined.
Reactivity: Human PBL. Tonsil
Concentration: 0.2mg/ml
Storage: Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
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