CDX4 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6132a
Background:
CDX4 is a member of the 'caudal-related' family of homeo box genes. It is located in the mouse 100 kb distal to Xist, and the 2 genes are transcribed convergently. It has been demonstrated that CDX4 is located proximal to XIST in the human.1 In contrast to Xist, Cdx4 appears to be normally X-inactivated in mice. CDX4 is identified as the locus mutated in 'kugelig' (kgg), a zebrafish mutant with an early defect in hematopoiesis that is associated with abnormal anteroposterior patterning and aberrant hox gene expression.2 A series of evidence from the zebrafish mutant model suggests that cdx4 regulates hox genes and is necessary for the specification of hematopoietic cell fate during vertebrate embryogenesis.
Other Names:
Homeobox protein CDX-4, Caudal-type homeobox protein 4, CDX4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6132a was selected from the N-term region of human CDX4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CDX4
Gene ID: 1046
Primary Accession: O14627
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
CDX4 is a member of the 'caudal-related' family of homeo box genes. It is located in the mouse 100 kb distal to Xist, and the 2 genes are transcribed convergently. It has been demonstrated that CDX4 is located proximal to XIST in the human.1 In contrast to Xist, Cdx4 appears to be normally X-inactivated in mice. CDX4 is identified as the locus mutated in 'kugelig' (kgg), a zebrafish mutant with an early defect in hematopoiesis that is associated with abnormal anteroposterior patterning and aberrant hox gene expression.2 A series of evidence from the zebrafish mutant model suggests that cdx4 regulates hox genes and is necessary for the specification of hematopoietic cell fate during vertebrate embryogenesis.
Other Names:
Homeobox protein CDX-4, Caudal-type homeobox protein 4, CDX4
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6132a was selected from the N-term region of human CDX4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: CDX4
Gene ID: 1046
Primary Accession: O14627
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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