CEBP Beta polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
CCAAT/enhancer-binding protein beta, also known as is CEBP-beta, is a protein that in humans is encoded by the CEBPB gene. It mapped to 20q13.13. The protein encoded by this intronless gene is a bZIP transcription factor that can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. CEBP-beta is critical for normal macrophage functioning, an important immune cell sub-type. Observational work has shown that expression of CEBP-beta in blood leukocytes is positively associated with muscle strength in humans, emphasizing the importance of the immune system, and particularly macrophages, in the maintenance of muscle function.

Description:
Rabbit IgG polyclonal antibody for CCAAT/enhancer-binding protein beta (CEBPB) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
AGP/EBP antibody, C EBP beta antibody, C/EBP beta antibody, C/EBP related protein 2 antibody, CCAAT Enhancer Binding Protein beta antibody, CCAAT/enhancer-binding protein beta antibody, CEBPB antibody, CEBPB_HUMAN antibody, CRP2 antibody, IL 6DBP antibody, IL6DBP antibody, Interleukin 6 dependent binding protein antibody, LAP antibody, Liver activator protein antibody, Liver enriched transcriptional activator antibody, NF IL6 antibody, NFIL6 antibody, Nuclear factor NF IL6 antibody, Nuclear factor NF-IL6 antibody, SF B antibody, SFB antibody, Silencer factor B antibody, TCF-5 antibody, TCF5 antibody, Transcription factor 5 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human CEBP Beta recombinant protein (Position: M1-A200). Human CEBP Beta shares 61% amino acid (aa) sequence identity with both mouse and rat CEBP Beta.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.