CELA3B / ELA3B (Pancreatic Function Marker) (clone CELA3B/1218 ), anti-human
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In stock
SKU
AC-AH11228
Catalog Number: AC-AH11228
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: CELA3B/1218
Applications: IF, FC
Datasheet
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Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: CELA3B/1218
Applications: IF, FC
Datasheet
Request Information
Background:
This MAb recognizes a protein of ~17kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Other Names:
Chymotrypsin-like elastase family member 3B, 3.4.21.70, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
Gene Name: CELA3B
Gene ID: 23436
Primary Accession: P08861
Other Accession: 23436, 728752
This MAb recognizes a protein of ~17kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Other Names:
Chymotrypsin-like elastase family member 3B, 3.4.21.70, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
Gene Name: CELA3B
Gene ID: 23436
Primary Accession: P08861
Other Accession: 23436, 728752
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