CENPC polyclonal, anti-human

Background:
A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The evolutionarily conserved Centromere Protein-C, CENP-C, is a kinetochore assembly protein. CENP-C is located on the fibers of the kinetochore and constitutes a kinetochore organizing center that tightly associates with DNA. CENP-C is necessary for the formation of a functional centromere, which indicates that CENP-C is important for mitotic progression. In addition, CENP-C is lost from centromeres during herpes simplex virus 1 infection, causing substantial structural changes in the kinetochore, which suggests that the structure of CENP-C is regulated during the cell cycle.

Alternative Name:
CENP-C, CENP-C 1, CENP-C 1, CENP-C, CENPC, CENPC1, Centromere autoantigen C, Centromere autoantigen C1, Centromere protein C 1, Centromere protein C, hcp-4, ICEN7, Interphase centromere complex protein 7, MIF2,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:200
IP:1:10-1:50

Specificity: CENPC polyclonal antibody detects endogenous levels of CENPC protein.

Immunogen:
Recombinant protein within human CENPC aa 400-600.

MW: 107 kDa

Swiss-Prot: Q03188(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.