CENPF Polyclonal Antibody

Background:
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
AH antigen, Cell cycle dependent 350K nuclear protein, CENF, CENP F, CENP F kinetochore protein, CENP-F, CENPF, CENPF kinetochore protein, CENPF, Centromere protein F 350/400ka, Centromere protein F, Centromere protein F, 350/400kDa, CILD31, Hcp 1, Hcp1, Kinetochore protein CENP F, Kinetochore protein CENPF, Mitosin, PRO1779, STROMS

Immunogen: Synthetic peptide of human CENPF

Swissprot: P49454
Gene Accession: NP057427

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.3 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.