CENPT C-terminal region polyclonal, anti-human, mouse, rat, rabbit, pig, bovine, guinea pig, dog

Background:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome- associated complex that binds specifically to histone H3- containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.

Other Names:
Centromere protein T, CENP-T, Interphase centromere complex protein 22, CENPT, C16orf56, ICEN22

Immunogen:
The immunogen for Anti-CENPT antibody is: synthetic peptide directed towards the C-terminal region of Human CENPT

Gene Name:
CENPT
Gene Name:
80152
NCBI Accession:
NP_079358
Primary Accession: Q96BT3
Other Accession: NM_025082;NP_079358
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.