CEP170 rabbit polyclonal, anti-human, mouse, rat

Backgroud: centrosomal protein 170(CEP170) Homo sapiens The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],function:Plays a role in microtubule organization.,PTM:Phosphorylated; probably by PLK1. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CEP170 family.,similarity:Contains 1 FHA domain.,subcellular location:Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.,subunit:Interacts with PLK1.,

Synonyms: CEP170, FAM68A, KAB, KIAA0470, Centrosomal protein of 170 kDa, Cep170, KARP-1-binding protein, KARP1-binding protein

Gene Name: CEP170

Gene ID: 9859

SwissProt ID: Q5SW79

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.