CERS4 Polyclonal Antibody

Background:
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
ceramide synthase 4, CerS4, FLJ12089, LAG1 homolog ceramide synthase 4, LAG1 longevity assurance homolog 4, LAG1, S. cerevisiae, homolog of, 4, LASS 4, LASS4, LASS4 LAG1 homolog ceramide synthase 4, LASS4, TRAM homolog 1, Trh 1, Trh1

Immunogen: Synthetic peptide of human CERS4

Swissprot: Q9HA82
Gene Accession: NP_078828

Calculated MW: 46 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-65112/sc-65113