CERS6 Polyclonal Antibody

Background:
The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they all are involved in sphingolipid synthesis. LASS6 is a widely expressed 384 amino acid endoplasmic reticulum, multi-pass membrane protein. On the luminal side of the endoplasmic reticulum membrane, the N-terminal asparagine residue is glycosylated. In cells deficient for CLN9, LASS6 corrects growth and apoptosis, and increases the levels of short ceramide species, such as C14:0- and C16:0-ceramides.

Research Area: Cancer, Metabolism, Signal transduction

Synonyms:
Ceramide synthase 6, CerS 6, CERS5, CerS6, LAG1 homolog ceramide synthase 6, LAG1 longevity assurance homolog 6, LASS 6, Lass6, LASS6, Longevity assurance homolog 6, MGC129949, MGC129950, T1L

Immunogen: Synthetic peptide of human CERS6

Swissprot: Q6ZMG9
Gene Accession: NP_982288

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-65127