CFB polyclonal, anti-human
€388.00
In stock
SKU
BS7289
Background:
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Alternative Name:
AHUS4, B factor properdin, BF, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, CFAB, CFAB_HUMAN, CFB, Complement Factor B, Complement factor B Bb fragment, FB, FBI12, GBG, Glycine rich beta glycoprotein, Glycine-rich beta glycoprotein, H2 Bf, H2BF, PBF2, Properdin factor B,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: CFB polyclonal antibody detects endogenous levels of CFB protein.
Immunogen:
Recombinant full length Human CFB.
MW: ~ 86 kDa
Swis Prot.: P00751
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Alternative Name:
AHUS4, B factor properdin, BF, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, CFAB, CFAB_HUMAN, CFB, Complement Factor B, Complement factor B Bb fragment, FB, FBI12, GBG, Glycine rich beta glycoprotein, Glycine-rich beta glycoprotein, H2 Bf, H2BF, PBF2, Properdin factor B,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: CFB polyclonal antibody detects endogenous levels of CFB protein.
Immunogen:
Recombinant full length Human CFB.
MW: ~ 86 kDa
Swis Prot.: P00751
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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