CFHR5 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP5689C
Catalog Number: AC-AP5689C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22505
Applications: FC, IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22505
Applications: FC, IHC-P, WB
Datasheet
Request Information
Background:
CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene familycontains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq].
Other Names:
Complement factor H-related protein 5, FHR-5, CFHR5, CFHL5, FHR5
Target/Specificity:
This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.
Antigen Region:
203-231
Antigen Type: Synthetic Peptide
Gene Name: CFHR5
Gene ID: 81494
Primary Accession: Q9BXR6
NCBI Accession: NP_110414.1
Other Accession: NP_110414.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
CFHR5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene familycontains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq].
Other Names:
Complement factor H-related protein 5, FHR-5, CFHR5, CFHL5, FHR5
Target/Specificity:
This CFHR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-231 amino acids from the Central region of human CFHR5.
Antigen Region:
203-231
Antigen Type: Synthetic Peptide
Gene Name: CFHR5
Gene ID: 81494
Primary Accession: Q9BXR6
NCBI Accession: NP_110414.1
Other Accession: NP_110414.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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