CFL1 Polyclonal Antibody

Background:
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.

Research Area: Cancer, Cardiovascular, Neuroscience, Signal Transduction

Synonyms:
18 kDa phosphoprotein, CFL 1, CFL, CFL1, COF1, Cofilin 1, Cofilin 1 non muscle, Cofilin, Cofilin non muscle isoform, Cofilin-1, epididymis secretory protein Li 15, HEL-S-15, non-muscle isoform, p18

Immunogen: Recombinant human Homeobox protein Cofilin-1 protein

Swissprot: P23528

Calculated MW: 17 kDa
Observed MW: 17 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Concentration: 2 mg/mL
Dilution: WB 1:500-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.