CFTR polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Cystic fibrosis transmembrane conductance regulator(CFTR), also called ABC35 or ABCC7, is a protein that in humans is encoded by the CFTR gene. This gene is mapped to 7q31.2. This gene encodes a member of the ATP-binding cassette(ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies(ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens.

Description:
Rabbit IgG polyclonal antibody for Cystic fibrosis transmembrane conductance regulator (CFTR) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ABC 35 antibody, ABC35 antibody, ABCC 7 antibody, ABCC7 antibody, ATP binding cassette sub family C member 7 antibody, ATP Binding Cassette Superfamily C Member 7 antibody, ATP binding cassette transporter sub family C member 7 antibody, ATP-binding cassette sub-family C member 7 antibody, cAMP dependent chloride channel antibody, cAMP-dependent chloride channel antibody, CF antibody, CFTR antibody, CFTR/MRP antibody, CFTR_HUMAN antibody, Channel conductance controlling ATPase antibody, Channel conductance-controlling ATPase antibody, Cystic fibrosis transmembrane conductance regulator antibody, Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7 antibody, Cystic Fibrosis Transmembrane Regulator antibody, dJ760C5.1 antibody, MRP 7 antibody, MRP7 antibody, TNR CFTR antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human CFTR(1463-1480aa QIAALKEETEEEVQDTRL), different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.A synthetic peptide corresponding to a sequence at the C-terminus of human CFTR(1463-1480aa QIAALKEETEEEVQDTRL), different from the related mouse sequence by two amino acids, and from the related rat sequence by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.