CFTR polyclonal, anti-human, mouse, rat

Background:
EEpithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Exerts its function also by modulating the activity of other ion channels and transporters . Plays an important role in airway fluid homeostasis . Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 . Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Alternative Name:
CFTR, ABCC7, ABC 35, ABC35, ABCC 7, ABCC7, ATP binding cassette sub family C member 7, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, cAMP dependent chloride channel, cAMP-dependent chloride channel, CF, CFTR, CFTR/MRP, CFTR, Channel conductance controlling ATPase, Channel conductance-controlling ATPase, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, Cystic Fibrosis Transmembrane Regulator, dJ760C5.1, MRP 7, MRP7, TNR CFTR,

Application Dilution:
WB:1:500-1:1,000
ICC:1:50-1:500
IHC:1:50-1:20
FC:1:50-1:100

Specificity: CFTR polyclonal antibody detects endogenous levels of CFTR protein.

Immunogen:
Synthetic peptide within C-terminal human CFTR.

MW: 168/69 kDa (Predicted band size)

Swiss-Prot: P13569(Human) P26361(Mouse) P34158(Rat)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.