CGAS Polyclonal Antibody

Background:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2', 5' phosphodiester linkage at the GpA step and the formation of a 3', 5' phosphodiester linkage at the ApG step, producing c[G(2', 5')pA(3', 5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).

Research Area: Cell Biology

Synonyms:
C6orf150, cGAMP synthase, cGAS, CGAS, cGMP Synthase, Chromosome 6 open reading frame 150, Cyclic GMP-AMP synthase, h-cGAS, Hypothetical protein LOC115004, Mab 21 domain containing 1, Mab-21 domain-containing protein 1, MB21D1, MGC131892, MGC142166, MGC142168, OTTHUMP00000016743, OTTHUMP00000039330, protein MB21D1, Uncharacterized protein C6orf150

Immunogen: Synthetic peptide of human MB21D1

Swissprot: Q8N884
Gene Accession: NP612450

Calculated MW: 59 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.78 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.