CGRP (Calcitonin gene-related peptide) polyclonal, anti-human, mouse, rat

Quantity: 50 µl

Background:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms:
CALCA, CALC1, CGRP, CGRP-I, CGRP1, CT, KC

Isotype: Guinea Pig Polyclonal

Immunogen:
Calcitonin gene-related peptide (synthetic, rat), conjugated to BSA

Form: Serum containing 0.1% sodium azide

Specificity:
Absorption with 10-100 ?g CGRP per ml diluted antiserum abolishes the staining while calcitonin, substance P and Neurokinin A do not.

Reactivity: human, mouse, rat

Applications: Immunofluorescence, Immunohistochemistry on paraffin and frozen sections

Working DIlution: 1:80 to 1:120

Positive Control:
Frozen sections of rat colon

Storage: 2-8C for immediate use, or at -20C (aliquot)

References:
- Mulder H. et al. (1995) J Neuroscience 15 (11): 7625-7632