CHD3 (C-term (clone 7F6-G2-E5), anti-human, mouse, rat

Background:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Synonyms: Mi-2a, Mi2-ALPHA, ZFH

Cellular Location: Cytoplasm Nucleus centrosome cytoskeleton microtubule organizing center

Immunogen:
Purified recombinant human CHD3 (C-terminus) protein fragments expressed in E.coli.

Gene Symbol: CHD3(C-term)

Gene ID: 1107

Swiss prot: Q12873

Calculated MW: 260kDa

Recommended dilution:
WB 1:1000, ICC 1:400

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.