CHD3 Polyclonal Antibody

Background:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology

Synonyms:
CHD3, Mi-2a, Mi2-ALPHA, ZFH

Immunogen: A synthetic peptide of human CHD3 (NP_001005273.1).

Swissprot: Q12873
Gene ID: 1107

Calculated MW: 222 kDa/226 kDa/233 kDa
Observed MW: 280 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:200-1:1000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.